Risk Factors for Development of Breast Cancer (A to G Guide)
For easy remembrance of the risk factors that can cause
breast cancer, it is grouped into 7 major titles that start from A to G, and
under each heading both protective factors or factors that has least causative
effect and factors that has strong risk are classified and described.
 |
| Risk Factors for development of Breast Carcinoma |
|
|
|
Risk
|
Protective
|
|
A
|
Age
|
Old age
>90 years (~20%)
|
Rare <20 years
|
|
B
|
Benign Breast Conditions
|
Hyperplasia (1.5-3 fold)
Papilloma (1.5-3 fold)
Ductal / Lobular Atypical hyperplasia (5 fold)
|
|
|
C
|
Cancer
|
Cancer of contralateral Breast (3-4 fold)
Cervix
Ovary
Colon
Prostate
Radiation Therapy for Hodgkin's Lymphoma
|
|
|
D
|
Diet
|
Alcohol
Phytoestrogen Deficiency
|
Vitamin C
|
|
E
|
Estrogen
(Conversion of Steroid hormone to estradiol in the body fat)
|
Nulliparous
Obese Postmenopausal Women
Exogenous Estrogen (OCP, Mixed prep HRT)
|
Breast feeding
Late Menarche
Early Menopause
Early age at 1st child birth
|
|
F
|
Familial History
|
2-10 fold risk in family history of Breast, Colon, Ovarian and
Prostate Carcinoma
|
|
|
G
|
Genetics
|
BRCA 1 (Breast Ovarian, prostate and Colorectal Ca )
BRCA2 (Male Breast Ca)
p53
HER 2
|
|
|
G
|
Geography
|
African american
(Western world 1-3 % of all death of women )
|
Rare in Japan and Taiwan
|
Source: Bailey and Love’s Short Practice of Surgery.
