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Thursday, August 31, 2017

Mnemonics: Breast Cancer causes

Risk Factors for Development of Breast Cancer (A to G Guide)

For easy remembrance of the risk factors that can cause breast cancer, it is grouped into 7 major titles that start from A to G, and under each heading both protective factors or factors that has least causative effect and factors that has strong risk are classified and described.
Risk Factors for development of Breast Carcinoma




Risk
Protective
A
Age
Old age
>90 years (~20%)
Rare <20 years
B
Benign Breast Conditions
Hyperplasia (1.5-3 fold)
Papilloma (1.5-3 fold)
Ductal / Lobular Atypical hyperplasia (5 fold)

C
Cancer
Cancer of contralateral Breast (3-4 fold)
Cervix
Ovary
Colon
Prostate
Radiation Therapy for Hodgkin's Lymphoma

D
Diet
Alcohol
Phytoestrogen Deficiency
Vitamin C
E
Estrogen
(Conversion of Steroid hormone to estradiol in the body fat)
Nulliparous
Obese Postmenopausal Women
Exogenous Estrogen (OCP, Mixed prep HRT)
Breast feeding
Late Menarche
Early Menopause
Early age at 1st child birth
F
Familial History
2-10 fold risk in family history of Breast, Colon, Ovarian and Prostate Carcinoma

G
Genetics
BRCA 1 (Breast Ovarian, prostate and Colorectal Ca )
BRCA2 (Male Breast Ca)
p53
HER 2

G
Geography
African american
(Western world 1-3 % of all death of women )
Rare in Japan and Taiwan
Source: Bailey and Love’s Short Practice of Surgery.

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