Risk Factors for Development of Breast Cancer (A to G Guide)
For easy remembrance of the risk factors that can cause
breast cancer, it is grouped into 7 major titles that start from A to G, and
under each heading both protective factors or factors that has least causative
effect and factors that has strong risk are classified and described.
Risk Factors for development of Breast Carcinoma |
|
|
Risk
|
Protective
|
A
|
Age
|
Old age
>90 years (~20%)
|
Rare <20 years
|
B
|
Benign Breast Conditions
|
Hyperplasia (1.5-3 fold)
Papilloma (1.5-3 fold)
Ductal / Lobular Atypical hyperplasia (5 fold)
|
|
C
|
Cancer
|
Cancer of contralateral Breast (3-4 fold)
Cervix
Ovary
Colon
Prostate
Radiation Therapy for Hodgkin's Lymphoma
|
|
D
|
Diet
|
Alcohol
Phytoestrogen Deficiency
|
Vitamin C
|
E
|
Estrogen
(Conversion of Steroid hormone to estradiol in the body fat)
|
Nulliparous
Obese Postmenopausal Women
Exogenous Estrogen (OCP, Mixed prep HRT)
|
Breast feeding
Late Menarche
Early Menopause
Early age at 1st child birth
|
F
|
Familial History
|
2-10 fold risk in family history of Breast, Colon, Ovarian and
Prostate Carcinoma
|
|
G
|
Genetics
|
BRCA 1 (Breast Ovarian, prostate and Colorectal Ca )
BRCA2 (Male Breast Ca)
p53
HER 2
|
|
G
|
Geography
|
African american
(Western world 1-3 % of all death of women )
|
Rare in Japan and Taiwan
|
Source: Bailey and Love’s Short Practice of Surgery.
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