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Friday, September 12, 2014

Poison and Their Antidote

Link: Classification of Poison
S. No.
Name of the poison
Name of Antidote
Dose
Remarks
1
Abrin
Antiabrin


2
Arsenic
BAL(British Anti Lewisite)
+ Freshly prepared Ferrous Sulfate
400-800mg
200-400mg
100-200mg
Day 1-2
Day 3-4-5
Subsequent days until urine level <50μg/dl
3
Benzodiazepine
Flumazenil
0.5mg iv over 30s

4
Botulinum
Guanidine


5
Carbonmonoxide
Carbogen
(95% O2 + 5% CO2)

Adrenaline
0.5ml – 1ml

Coramine
5ml

6
Copper
Freshly prepared Potassium Ferrocyanide

forms Cupric Ferrocyanide
Penicillamine

EDTA BAL
7
Curare
Neostigmine
Edrophonium
Pyridostigmine


8
Cyanide
Eli Lilli Cyanide Aprroach Kit

Others
Cobalt EDTA
4DMAP
Amyl Nitrite
1 perle of 0.2ml crushed and inhaled every 30s
Sodium Nitrite
3% solution 0.33ml/kg iv over 10-20 min
Sodium Thiosulphate
25% solution
3-5ml/min (max 60 ml)
9
Dhatura
Physostigmine
0.5mg im

10
Ethylene glycol
4 Methyl pyrazole/ Fomepizole

Ethanol
11
Formic Acid
Folinic Acid
1mg/kg loading with maintainence of 0.5mg/kg
Fomepizol
12
Iron
Desferroxamine
1g im
500mg q4h 2 doses
500mg q4-12h (max 6g in 24 hr)

13
Lead
EDTA / BAL
18mg/kg/day
12mg/kg/day 6mg/kg/day
Day 1-2
Day 3-4-5
Day 6-7
14
Mercury
BAL
3.5mg/kg/q4h
2.5mg/kg/q6h
2.5mg/kg/bd
2 days
1 day
according to severity
15
Methanol
Folinic  Acid

Fomepizole
Ethanol
10mg/kg iv for 30 min OR
1mg/kg of 95% ethanol in fruit juice

16
Organophosphate
Atropine
2mg iv every 10-15min unless atropnized
Edrin though OP has no antidote
Pralidoxime
1-2g iv over 5-30min repeated every 30min

17
Oxalic Acid
Calcium Gluconate


18
Paracetamol
N-acetylcysteine
150mg/kg iv infusion over 15 min

19
Phosphorus
CuSO4
0.1%


20
Snake Bite
Anivenin

Polyvalent
Monovalent

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